SD 2590 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4775
Potent MMP inhibitor
Key Product Details
Description
Potent MMP inhibitor
Alternative Names
SC 78080
Product Description
SD 2590 hydrochloride is a potent MMP inhibitor (IC50 values are <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3 respectively). Exhibits 100,000-fold selectivity for MMP-2 and -13 over MMP-1. Reduces left ventricular dilation in a myocardial infarction rat model. Orally bioavailable.Licensing Information
Sold for research purposes under agreement from Pfizer IncProduct Specifications
Molecular Weight
554.96
Formula
C22H25F3N2O7S.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-4-piperidinecarboxamide hydrochloride
CAS Number
226395-93-3
PubChem ID
9893894
InChI Key
HJJOIVGDTLHVTK-UHFFFAOYSA-N
SMILES
O=S(C1(C(NO)=O)CCN(CCOC)CC1)(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 55.5 | 100 | |
| DMSO | 55.5 | 100 |
Preparing Stock Solutions
for SD 2590 hydrochloride
The following data is based on the product molecular weight 554.96
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.80 mL | 9.01 mL | 18.02 mL |
| 5 mM | 0.36 mL | 1.80 mL | 3.60 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.80 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for SD 2590 hydrochloride
For research use only
Loading...
Loading...