SD 208

Tocris Bioscience, part of Bio-Techne | Catalog # 3269

COA / SDS

Potent ATP-competitive TGF-βRI inhibitor

Key Product Details

Description:	Potent ATP-competitive TGF-βRI inhibitor
Chemical Name:	2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
Purity:	≥98% (HPLC)
Molecular Weight:	352.75

View Full Technical Details for SD 208

Technical Data
Citations

Biological Activity for SD 208

SD 208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC₅₀ = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. Also promotes an antiglioma immune response. Ameliorates germinal matrix hemorrhage-induced neurological deficits in neonatal rats.

Compound Libraries for SD 208

SD 208 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SD 208

M. Wt	352.75
Formula	C₁₇H₁₀ClFN₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	627536-09-8
PubChem ID	10316032
InChi Key	BERLXWPRSBJFHO-UHFFFAOYSA-N
Smiles	FC(C=CC(Cl)=C3)=C3C2=NC1=NC=CN=C1C(NC4=CC=NC=C4)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SD 208

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.05	20 with gentle warming

Preparing Stock Solutions for SD 208

The following data is based on the product molecular weight 352.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.17 mL	70.87 mL	141.74 mL
1 mM	2.83 mL	14.17 mL	28.35 mL
2 mM	1.42 mL	7.09 mL	14.17 mL
10 mM	0.28 mL	1.42 mL	2.83 mL

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Reconstitution Calculator

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References for SD 208

References are publications that support the biological activity of the product.

Manaenko Inhibition of transforming growth factor-β attenuates brain injury and neurological deficits in a rat model of germinal matrix hemorrhage. Stroke 2014 PMID: 24425124
Kapoun Transforming growth factor-β receptor type I receptor (TGFβRI) kinase activity but not p38 activation is required for TGFβRI-induced myofibroblast differentiation and profibrotic gene expression. Mol.Pharmacol. 2006 PMID: 16707625
Leung Effect of transforming growth factor-β receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling. J.Pharmacol.Exp.Ther. 2006 PMID: 16888081
Uhl SD-208, a novel transforming growth factor β feceptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogeneicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004 PMID: 15520202