SD 208
Tocris Bioscience, part of Bio-Techne | Catalog # 3269
Potent ATP-competitive TGF-βRI inhibitor
Key Product Details
Description
Potent ATP-competitive TGF-βRI inhibitor
Product Description
SD 208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50 = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. Also promotes an antiglioma immune response. Ameliorates germinal matrix hemorrhage-induced neurological deficits in neonatal rats.Product Specifications
Molecular Weight
352.75
Formula
C17H10ClFN6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
CAS Number
627536-09-8
PubChem ID
10316032
InChI Key
BERLXWPRSBJFHO-UHFFFAOYSA-N
SMILES
FC(C=CC(Cl)=C3)=C3C2=NC1=NC=CN=C1C(NC4=CC=NC=C4)=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.05 | 20 with gentle warming |
Preparing Stock Solutions
for SD 208
The following data is based on the product molecular weight 352.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.17 mL | 70.87 mL | 141.74 mL |
| 1 mM | 2.83 mL | 14.17 mL | 28.35 mL |
| 2 mM | 1.42 mL | 7.09 mL | 14.17 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.83 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Manaenko Inhibition of transforming growth factor-β attenuates brain injury and neurological deficits in a rat model of germinal matrix hemorrhage. Stroke 2014 PMID: 24425124
- Kapoun Transforming growth factor-β receptor type I receptor (TGFβRI) kinase activity but not p38 activation is required for TGFβRI-induced myofibroblast differentiation and profibrotic gene expression. Mol.Pharmacol. 2006 PMID: 16707625
- Leung Effect of transforming growth factor-β receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling. J.Pharmacol.Exp.Ther. 2006 PMID: 16888081
- Uhl SD-208, a novel transforming growth factor β feceptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogeneicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004 PMID: 15520202
Product Specific Notices for SD 208
For research use only
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