SCH 58261

Name: SCH 58261
Brand: Tocris Bioscience
SKU: 2270

Tocris Bioscience, part of Bio-Techne | Catalog # 2270

Citations (206)

COA / SDS

Potent, highly selective A2A antagonist

Key Product Details

Description:	Potent, highly selective A_2A antagonist
Chemical Name:	2-(2-Furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Purity:	≥99% (HPLC)
Molecular Weight:	345.36

View Full Technical Details for SCH 58261

Technical Data
Citations

Biological Activity for SCH 58261

SCH 58261 is a potent and selective A_2A adenosine receptor competitive antagonist (K_i = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A₁, A_2B and A₃ receptors, respectively. Reduces melanoma tumor growth and TGF-β levels in WT and P2X7R-null mice.

Compound Libraries for SCH 58261

SCH 58261 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SCH 58261

M. Wt	345.36
Formula	C₁₈H₁₅N₇O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	160098-96-4
PubChem ID	176408
InChi Key	UTLPKQYUXOEJIL-UHFFFAOYSA-N
Smiles	NC1=NC2=C(C=NN2CCC2=CC=CC=C2)C2=NC(=NN12)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 58261

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.54	100

Preparing Stock Solutions for SCH 58261

The following data is based on the product molecular weight 345.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.90 mL	14.48 mL	28.96 mL
5 mM	0.58 mL	2.90 mL	5.79 mL
10 mM	0.29 mL	1.45 mL	2.90 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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Reconstitution Calculator

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References for SCH 58261

References are publications that support the biological activity of the product.

De Marchi A2A receptor contributes to tumor progression in P2X7 null mice. Front.Cell Dev.Biol. 2022 PMID: 35663396
Bastia Effects of A₁ and A_2A adenosine receptor ligands in mouse acute models of pain. Neurosci.Lett. 2002 PMID: 12147316
Belardinelli The A_2A adenosine receptor mediates coronary vasodilation. J.Pharmacol.Exp.Ther.
Zocchi Binding of the radioligand [³H]-SCH 58261, a new non-xanthine A_2A adenosine receptor antagonist, to rat striatal membranes. J.Pharmacol.Exp.Ther. 1996 PMID: 8632302