SCH 442416

Tocris Bioscience, part of Bio-Techne | Catalog # 2463

Very selective, high affinity A2A antagonist
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Key Product Details

Description

Very selective, high affinity A2A antagonist

View all Adenosine A2a Receptor Antagonists »

Product Description

SCH 442416 is a selective adenosine A2A receptor antagonist; binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively). Displays > 23000-fold selectivity for hA2A over hA1 in vitro with minimal affinity for hA2B and hA3 receptors (IC50 > 10 μM). Blocks the cytoprotective effect of A2A agonist CGS-21680 (Cat.No. 1063).

Product Specifications

Molecular Weight

389.42

Formula

C20H19N7O2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine

CAS Number

316173-57-6

PubChem ID

10668061

InChI Key

AEULVFLPCJOBCE-UHFFFAOYSA-N

SMILES

COC1=CC=C(CCCN2N=CC3=C2N=C(N)N2N=C(N=C32)C2=CC=CO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.94 100

Preparing Stock Solutions for SCH 442416

The following data is based on the product molecular weight 389.42

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SCH 442416

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SCH 442416

For research use only

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