SCH 39166 hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 2299
High affinity D1-like antagonist
Key Product Details
Description
High affinity D1-like antagonist
Alternative Names
Ecopipam hydrobromide
Product Description
SCH 39166 hydrobromide is a high affinity dopamine D1/D5 receptor antagonist; displays Ki values of 1.2, 2, 980, 5520, 80 and 731 nM for binding to D1, D5, D2, D4, 5-HT and α2a receptors, respectively.Product Specifications
Molecular Weight
394.73
Formula
C19H20ClNO.HBr
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(6aS-trans)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide
CAS Number
1227675-51-5
PubChem ID
16759171
InChI Key
GAUWIDFICGEZKR-JUOYHRLASA-N
SMILES
Br.CN1CCC2=C(C=C(O)C(Cl)=C2)[C@@H]2[C@@H]1CCC1=CC=CC=C21
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.47 | 100 |
Preparing Stock Solutions
for SCH 39166 hydrobromide
The following data is based on the product molecular weight 394.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.67 mL | 25.33 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Terry and Katz A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behaviour by the D1 agonist SKF38393. Psychopharmacology 1994 PMID: 7862841
- McQuade In vivo binding of SCH 39166: a D-1 selective antagonist. J.Pharmacol.Exp.Ther. 1991 PMID: 1826927
- Wu DA D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists. J.Med.Chem. 2005 PMID: 15689153
Product Specific Notices for SCH 39166 hydrobromide
For research use only
Loading...
Loading...