SC 58125

Name: SC 58125
Brand: Tocris Bioscience
SKU: 2895

Tocris Bioscience, part of Bio-Techne | Catalog # 2895

Citations (111)

COA / SDS

Selective cyclooxygenase-2 (COX-2) inhibitor

Discontinued Product

2895 has been discontinued. View all Cyclooxygenase Inhibitors products.

Key Product Details

Description:	Selective cyclooxygenase-2 (COX-2) inhibitor
Chemical Name:	5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
Purity:	≥98% (HPLC)
Molecular Weight:	384.35

View Full Technical Details for SC 58125

Technical Data
Citations

Biological Activity for SC 58125

SC 58125 is a selective cyclooxygenase 2 (COX-2) inhibitor (IC₅₀ values are 0.04 and >100 μM for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for SC 58125

M. Wt	384.35
Formula	C₁₇H₁₂F₄N₂O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	162054-19-5
PubChem ID	115239
InChi Key	JHBIMJKLBUMNAU-UHFFFAOYSA-N
Smiles	FC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(C)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SC 58125

References are publications that support the biological activity of the product.

Williams A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established colon cancer xenografts. Neoplasia 2001 PMID: 11687954
Seibert Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc.Natl.Acad.Sci.USA
Gierse A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 1996 PMID: 8663121