SC 26196

Tocris Bioscience, part of Bio-Techne | Catalog # 4189

Selective fatty acid desaturase 2 inhibitor
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Key Product Details

Description

Selective fatty acid desaturase 2 inhibitor

View all Lipid Metabolism Inhibitors »

Product Description

SC 26196 is a selective fatty acid desaturase 2 (FADS2, also known as Δ6 desaturase) inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over FADS1 and stearoly-CoA 9-desaturase (Δ5 desaturase and SCD-1/Δ9 desaturase, respectively) (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

423.55

Formula

C27H29N5

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

CAS Number

218136-59-5

PubChem ID

9845201

InChI Key

QFYKXKMYVYOUNJ-JBASAIQMSA-N

SMILES

N#CC(C3=CC=CC=C3)(C4=CC=CC=C4)CCCN1CCN(/N=C/C2=CN=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.59 25

Preparing Stock Solutions for SC 26196

The following data is based on the product molecular weight 423.55

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.44 mL 47.22 mL 94.44 mL
1.25 mM 1.89 mL 9.44 mL 18.89 mL
2.5 mM 0.94 mL 4.72 mL 9.44 mL
12.5 mM 0.19 mL 0.94 mL 1.89 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SC 26196

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SC 26196

For research use only

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