SB 699551
Tocris Bioscience, part of Bio-Techne | Catalog # 3188
Selective 5-ht5a antagonist
Product Description
SB 699551 is a selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively).Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
584.66
Formula
C34H45N3O.2HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride
CAS Number
864741-95-7
PubChem ID
11983346
InChI Key
QJMKBIHLMPTYTI-UHFFFAOYSA-N
SMILES
O=C(CCC4CCCC4)N(CCN(C)C)CC(C=C2)=CC=C2C1=CC=C(CNCCC3=CC=CC=C3)C=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.62 | 25 | |
| Ethanol | 5.85 | 10 |
Preparing Stock Solutions
for SB 699551
The following data is based on the product molecular weight 584.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 6.84 mL | 34.21 mL | 68.42 mL |
| 1.25 mM | 1.37 mL | 6.84 mL | 13.68 mL |
| 2.5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
| 12.5 mM | 0.14 mL | 0.68 mL | 1.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thomas 5-ht5A receptors as a therapeutic target. Pharmacol.Ther. 2006 PMID: 16516972
- Corbett Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg.Med.Chem.letts. 2005 PMID: 16002289
- Thomas SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an auto Neuropharmacology 2006 PMID: 16846620
Product Specific Notices for SB 699551
For research use only
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