SB 674042

Tocris Bioscience, part of Bio-Techne | Catalog # 4673

Potent and selective non-peptide OX1 antagonist
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Key Product Details

Description

Potent and selective non-peptide OX1 antagonist

View all OX1 Receptor Antagonists »

Product Description

SB 674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM). Exhibits 100-fold selectivity for OX1 over OX2 receptors. Has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors. Inhibits orexin 1-induced Ca2+ mobilization in CHO-DG44 cells stably transfected with the OX1 receptor.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications

Molecular Weight

448.51

Formula

C24H21FN4O2S

Storage

Store at +4°C

Chemical Name

[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone

CAS Number

483313-22-0

PubChem ID

10204153

InChI Key

HYBZWVLPALMACV-KRWDZBQOSA-N

SMILES

O=C(C2=C(C5=CC=CC=C5F)SC(C)=N2)N1[C@H](CC3=NN=C(C4=CC=CC=C4)O3)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.85 100
Ethanol 44.85 100

Preparing Stock Solutions for SB 674042

The following data is based on the product molecular weight 448.51

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.30 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Documents for SB 674042

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 674042

For research use only

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