SB 525334

Name: SB 525334
Brand: Tocris Bioscience
SKU: 3211

Tocris Bioscience, part of Bio-Techne | Catalog # 3211

Citations (51)

COA / SDS

Selective inhibitor of TGF-βRI

Key Product Details

Description:	Selective inhibitor of TGF-βRI
Chemical Name:	6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
Purity:	≥97% (HPLC)
Molecular Weight:	343.42

View Full Technical Details for SB 525334

Technical Data
Citations

Biological Activity for SB 525334

SB 525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC₅₀ = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries for SB 525334

SB 525334 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 525334

M. Wt	343.42
Formula	C₂₁H₂₁N₅
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	356559-20-1
PubChem ID	9967941
InChi Key	DKPQHFZUICCZHF-UHFFFAOYSA-N
Smiles	CC1=NC(C4=C(NC(C(C)(C)C)=N4)C2=CC=C(N=CC=N3)C3=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 525334

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.34	100

Preparing Stock Solutions for SB 525334

The following data is based on the product molecular weight 343.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.91 mL	14.56 mL	29.12 mL
5 mM	0.58 mL	2.91 mL	5.82 mL
10 mM	0.29 mL	1.46 mL	2.91 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for SB 525334

References are publications that support the biological activity of the product.

Higashiyama Inhibition of AVNreceptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis Exp.Mol.Pathol. 2007 PMID: 17274978
Laping Tumor-specific efficacy of transforming growth factor-βRI inhibition in eker rats. Clin.Cancer Res. 2007 PMID: 17505012
Grygielko Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-β type I receptor kinase in puromycin-induced nephritis. J.Pharmacol.Exp.Ther. 2005 PMID: 15769863