SB 525334

Tocris Bioscience, part of Bio-Techne | Catalog # 3211

Selective inhibitor of TGF-βRI
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Key Product Details

Description

Selective inhibitor of TGF-βRI

View all TGF-beta Receptor Inhibitors »

Product Description

SB 525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications

Molecular Weight

343.42

Formula

C21H21N5

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline

CAS Number

356559-20-1

PubChem ID

9967941

InChI Key

DKPQHFZUICCZHF-UHFFFAOYSA-N

SMILES

CC1=NC(C4=C(NC(C(C)(C)C)=N4)C2=CC=C(N=CC=N3)C3=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.34 100

Preparing Stock Solutions for SB 525334

The following data is based on the product molecular weight 343.42

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.56 mL 29.12 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
10 mM 0.29 mL 1.46 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SB 525334

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 525334

For research use only

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