SB 505124

Tocris Bioscience, part of Bio-Techne | Catalog # 3263

Selective inhibitor of TGF-βRI, ALK4 and ALK7
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Key Product Details

Description

Selective inhibitor of TGF-βRI, ALK4 and ALK7

View all TGF-beta Receptor Inhibitors »

Product Description

SB 505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members. Promotes adenine base editor activity in vivo and in vitro at 10 μM.

Product Specifications

Molecular Weight

335.40

Formula

C20H21N3O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine

CAS Number

694433-59-5

PubChem ID

9858940

InChI Key

WGZOTBUYUFBEPZ-UHFFFAOYSA-N

SMILES

CC(C)(C)C1=NC(C2=CC(OCO4)=C4C=C2)=C(C3=NC(C)=CC=C3)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.54 100
2eq. HCl 33.54 100

Preparing Stock Solutions for SB 505124

The following data is based on the product molecular weight 335.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.60 mL 2.98 mL 5.96 mL
10 mM 0.30 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.30 mL 0.60 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SB 505124

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 505124

For research use only

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