SB 3CT
Tocris Bioscience, part of Bio-Techne | Catalog # 6088
High affinity and selective MMP2 inhibitor
Key Product Details
Description
High affinity and selective MMP2 inhibitor
Product Description
SB 3CT is a selective high affinity MMP2 inhibitor (Ki = 28 nM); also inhibits MMP9 (Ki = 400 nM). Active in vivo, neuroprotective and blood-brain barrier permeable.Product Specifications
Molecular Weight
306.40
Formula
C15H14O3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane
CAS Number
292605-14-2
PubChem ID
9883002
InChI Key
LSONWRHLFZYHIN-UHFFFAOYSA-N
SMILES
O=S(CC1CS1)(C2=CC=C(C=C2)OC3=CC=CC=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.64 | 100 | |
| Ethanol | 6.13 | 20 |
Preparing Stock Solutions
for SB 3CT
The following data is based on the product molecular weight 306.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.26 mL | 16.32 mL | 32.64 mL |
| 5 mM | 0.65 mL | 3.26 mL | 6.53 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.26 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kleifeld X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. J.Biol.Chem. 2001 PMID: 11278946
- Gooyit Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem.Neurosci. 2012 PMID: 23077716
- Gu A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J.Neurosci. 2005 PMID: 16000631
Product Specific Notices for SB 3CT
For research use only
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