SB 334867

Tocris Bioscience, part of Bio-Techne | Catalog # 1960

Selective non-peptide OX1 antagonist
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Key Product Details

Description

Selective non-peptide OX1 antagonist

View all OX1 Receptor Antagonists »

Product Description

SB 334867 is a selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications

Molecular Weight

319.32

Formula

C17H13N5O2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea

CAS Number

792173-99-0

PubChem ID

6604926

InChI Key

AKMNUCBQGHFICM-UHFFFAOYSA-N

SMILES

CC1=NC2=CC=C(NC(=O)NC3=CC=NC4=CC=CN=C34)C=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.93 100 with gentle warming
Ethanol 3.19 10 with gentle warming

Preparing Stock Solutions for SB 334867

The following data is based on the product molecular weight 319.32

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SB 334867

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 334867

For research use only

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