SB 332235
Tocris Bioscience, part of Bio-Techne | Catalog # 5671
Potent CXCR2 antagonist
Product Description
SB 332235 is a potent CXCR2 antagonist (IC50 = 7.7 nM). Exhibits 285-fold selectivity for CXCR2 over CXCR1. Reduces leukocyte numbers in synovial fluid in acute and chronic rabbit arthritis models. Also reduces synovial fluid eicosanoid and cytokine levels in a rabbit chronic arthritis model. Inhibits proliferation of AML cell lines in vitro.Product Specifications
Molecular Weight
410.66
Formula
C13H10Cl3N3O4S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
6-Chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxybenzenesulfonamide
CAS Number
276702-15-9
PubChem ID
9887803
InChI Key
WTLRWOHEKQGKDS-UHFFFAOYSA-N
SMILES
ClC1=C(S(=O)(N)=O)C(O)=C(NC(NC2=C(Cl)C(Cl)=CC=C2)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.07 | 100 |
Preparing Stock Solutions
for SB 332235
The following data is based on the product molecular weight 410.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.18 mL | 24.35 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schinke IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells. Blood 2015 PMID: 25810490
- Podolin A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J.Immunol. 2002 PMID: 12444152
Product Specific Notices for SB 332235
For research use only
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