SB 239063

Name: SB 239063
Brand: Tocris Bioscience
SKU: 1962
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1962

(1)

Citations (76)

COA / SDS

Potent, selective p38 MAPK inhibitor; orally active

Key Product Details

Description:	Potent, selective p38 MAPK inhibitor; orally active
Chemical Name:	trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol
Purity:	≥98% (HPLC)
Molecular Weight:	368.41

View Full Technical Details for SB 239063

Technical Data
Citations / Reviews (1)

Biological Activity for SB 239063

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC₅₀ = 44 nM for p38α). Displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580 (Cat. Nos. 1202 and 1402). Reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for SB 239063

M. Wt	368.41
Formula	C₂₀H₂₁FN₄O₂
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	193551-21-2
PubChem ID	5166
InChi Key	ZQUSFAUAYSEREK-UHFFFAOYSA-N
Smiles	O[C@@H]1CC[C@@H](N2C=NC(C4=CC=C(F)C=C4)=C2C3=CC=NC(OC)=N3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 239063

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.68	10 with gentle warming

Preparing Stock Solutions for SB 239063

The following data is based on the product molecular weight 368.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.14 mL	135.72 mL	271.44 mL
0.5 mM	5.43 mL	27.14 mL	54.29 mL
1 mM	2.71 mL	13.57 mL	27.14 mL
5 mM	0.54 mL	2.71 mL	5.43 mL

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References for SB 239063

References are publications that support the biological activity of the product.

Legos The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injury. Eur.J.Pharmacol. 2002 PMID: 12106800
Underwood SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. J.Pharmacol.Exp.Ther. 2000 PMID: 10734180
Barone SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. J.Pharmacol.Exp.Ther. 2001 PMID: 11160612