SB 225002

Name: SB 225002
Brand: Tocris Bioscience
SKU: 2725
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2725

(1)

Citations (118)

COA / SDS

Potent and selective CXCR2 antagonist

Key Product Details

Description:	Potent and selective CXCR2 antagonist
Chemical Name:	N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	352.14

View Full Technical Details for SB 225002

Technical Data
Citations / Reviews (1)

Biological Activity for SB 225002

SB 225002 is a potent and selective CXCR2 chemokine receptor antagonist (IC₅₀ = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GROα-mediated calcium mobilization in HL60 cells (IC₅₀ values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo. Inhibits HIV replication in lymphocytes and macrophages.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for SB 225002

SB 225002 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 225002

M. Wt	352.14
Formula	C₁₃H₁₀BrN₃O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	182498-32-4
PubChem ID	3854666
InChi Key	MQBZVUNNWUIPMK-UHFFFAOYSA-N
Smiles	OC1=CC(=CC=C1NC(=O)NC1=CC=CC=C1Br)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 225002

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.21	100
	ethanol	17.61	50

Preparing Stock Solutions for SB 225002

The following data is based on the product molecular weight 352.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.20 mL	28.40 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for SB 225002

References are publications that support the biological activity of the product.

Lane Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy. J.Virol. 2001 PMID: 11483765
Catusse Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen a (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2. Biochem.Pharmacol. 2003 PMID: 12628493
White Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J.Biol.Chem. 1998 PMID: 9553055