SB 206553 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1661
Potent and selective 5-HT2B and 5-HT2C antagonist; orally active
Key Product Details
Description
Potent and selective 5-HT2B and 5-HT2C antagonist; orally active
Product Description
SB 206553 hydrochloride is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92). Displays > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6). Centrally active following oral administration in vivo.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
328.80
Formula
C17H16N4O.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
3,5-Dihydro-5-methyl-N-3-pyridinylbenzodipyrrole-1(2H)-carboxamide hydrochloride
CAS Number
1197334-04-5
PubChem ID
11957707
InChI Key
VGEMBOFBPSNOIO-UHFFFAOYSA-N
SMILES
Cl.CN1C=CC2=CC3=C(CCN3C(=O)NC3=CC=CN=C3)C=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.88 | 100 |
Preparing Stock Solutions
for SB 206553 hydrochloride
The following data is based on the product molecular weight 328.80
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.04 mL | 15.21 mL | 30.41 mL |
| 5 mM | 0.61 mL | 3.04 mL | 6.08 mL |
| 10 mM | 0.30 mL | 1.52 mL | 3.04 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Kennett In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties. Br.J.Pharmacol. 1996 PMID: 8821530
- Porras 5-HT2A and 5-HT2C/2B receptor subtypes modulate DA release induced in vivo by amphetamine and mor. in both the rat nucleus accumbens and striatum. Neuropsychopharmacology 2002 PMID: 11850146
- Forbes 5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity and oral activity. J.Med.Chem. 1995 PMID: 7629791
Product Specific Notices for SB 206553 hydrochloride
For research use only
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