SB 205607 dihydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 0921
Selective, high affinity non-peptide δ1 agonist
Key Product Details
Description
Selective, high affinity non-peptide δ1 agonist
Alternative Names
TAN 67
Product Description
The first described non-peptide δ1 opioid receptor agonist with very high affinity and selectivity for the δ1 subtype (Ki values are 1.12, 2320 and 1790 nM at δ1, μ and κ receptors respectively).Licensing Information
Sold under licenseProduct Specifications
Molecular Weight
506.28
Formula
C23H24N2O.2HBr
Storage
Store at RT
Purity
≥97% (HPLC)
Chemical Name
(R*,S*)-(±)-2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide
CAS Number
1217628-73-3
PubChem ID
56972161
InChI Key
GWXFBFMLKRAWEU-YJKXCHRFSA-N
SMILES
[H][C@@](C1)2[C@](CC(N=C(C=CC=C4)C4=C3)=C3C2)([C@]5=CC=CC(O)=C5)CCN1C.Br.Br
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50.63 | 100 | |
| DMSO | 50.63 | 100 |
Preparing Stock Solutions
for SB 205607 dihydrobromide
The following data is based on the product molecular weight 506.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.88 mL | 19.75 mL |
| 5 mM | 0.40 mL | 1.98 mL | 3.95 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nagase Syntheses of non-peptidic delta opioid agonists and their structure-activity relationships. Jpn.J.Pharmacol.
- Knap Properties of TAN-67, a non-peptidic β-opioid receptor agonist, at cloned human δ- and μ-opioid receptors. Eur.J.Pharmacol. 1995 PMID: 8566162
- Nagase The pharmacological profile of δ opioid receptor ligands (+) and (-) TAN-67 on pain modulation. Life Sci. 2001 PMID: 11358331
- Kamei Antinociceptive effects of the selective non-peptidic δ-opioid receptor agonist TAN-67 in diabetic mice. Eur.J.Pharmacol. 1995 PMID: 7781682
Product Specific Notices for SB 205607 dihydrobromide
For research use only
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