Saxagliptin hydrochloride

Name: Saxagliptin hydrochloride
Brand: Tocris Bioscience
SKU: 6507
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6507

(1)

Citations (1)

COA / SDS

High affinity DPP-IV inhibitor; active in vivo

Key Product Details

Description:	High affinity DPP-IV inhibitor; active in vivo
Alternative Names:	BMS 477118
Chemical Name:	(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	351.87

View Full Technical Details for Saxagliptin hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Saxagliptin hydrochloride

Saxagliptin hydrochloride is a high affinity DPP-IV inhibitor (K_i = 0.6 nM). Inhibits plasma DPP-IV (87%). Elicits enhanced glucose clearance in Zucker^fa/fa rats.

Compound Libraries for Saxagliptin hydrochloride

Saxagliptin hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Saxagliptin hydrochloride

M. Wt	351.87
Formula	C₁₈H₂₅N₃O₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	709031-78-7
PubChem ID	56841574
InChi Key	TUAZNHHHYVBVBR-RIKNOMPASA-N
Smiles	N[C@@H](C12CC3CC(C2)CC(C3)(C1)O)C(N4[C@H]5C[C@H]5C[C@H]4C#N)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Saxagliptin hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	35.19	100
	DMSO	35.19	100

Preparing Stock Solutions for Saxagliptin hydrochloride

The following data is based on the product molecular weight 351.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.21 mL	28.42 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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Reconstitution Calculator

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References for Saxagliptin hydrochloride

References are publications that support the biological activity of the product.

Augeri Discovery and preclinical profile of saxagl. (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J.Med.Chem. 2005 PMID: 16033281