Salubrinal
Tocris Bioscience, part of Bio-Techne | Catalog # 2347
Selective inhibitor of eIF2α dephosphorylation
Key Product Details
Description
Selective inhibitor of eIF2α dephosphorylation
Product Description
Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).Product Specifications
Molecular Weight
479.81
Formula
C21H17N4OSCl3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
CAS Number
405060-95-9
PubChem ID
5717801
InChI Key
LCOIAYJMPKXARU-VAWYXSNFSA-N
SMILES
S=C(NC(NC(/C=C/C3=CC=CC=C3)=O)C(Cl)(Cl)Cl)NC1=C2C(C=CC=N2)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.98 | 100 |
Preparing Stock Solutions
for Salubrinal
The following data is based on the product molecular weight 479.81
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.08 mL | 10.42 mL | 20.84 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.17 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.08 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Long Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett. 2005 PMID: 16002288
- Boyce A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 2005 PMID: 15705855
Product Specific Notices for Salubrinal
For research use only
Loading...
Loading...