Salubrinal

Name: Salubrinal
Brand: Tocris Bioscience
SKU: 2347

Tocris Bioscience, part of Bio-Techne | Catalog # 2347

Citations (120)

COA / SDS

Selective inhibitor of eIF2α dephosphorylation

Key Product Details

Description:	Selective inhibitor of eIF2α dephosphorylation
Chemical Name:	3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Purity:	≥98% (HPLC)
Molecular Weight:	479.81

View Full Technical Details for Salubrinal

Technical Data
Citations

Biological Activity for Salubrinal

Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC₅₀ ~ 15 μM).

Compound Libraries for Salubrinal

Salubrinal is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Salubrinal

M. Wt	479.81
Formula	C₂₁H₁₇N₄OSCl₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	405060-95-9
PubChem ID	5717801
InChi Key	LCOIAYJMPKXARU-VAWYXSNFSA-N
Smiles	S=C(NC(NC(/C=C/C3=CC=CC=C3)=O)C(Cl)(Cl)Cl)NC1=C2C(C=CC=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Salubrinal

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.98	100

Preparing Stock Solutions for Salubrinal

The following data is based on the product molecular weight 479.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.42 mL	20.84 mL
5 mM	0.42 mL	2.08 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for Salubrinal

References are publications that support the biological activity of the product.

Long Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett. 2005 PMID: 16002288
Boyce A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 2005 PMID: 15705855