SAK 3

Tocris Bioscience, part of Bio-Techne | Catalog # 6239

Potent CaV3.1 and 3.3 activator; orally bioavailable
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Key Product Details

Description

Potent CaV3.1 and 3.3 activator; orally bioavailable

View all Cav3.x Channel Activators »

Product Description

SAK 3 is a potent CaV3.1 and CaV3.3 activator. Enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Orally bioavailable.

Product Specifications

Molecular Weight

369.41

Formula

C20H23N3O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate

CAS Number

1256269-87-0

PubChem ID

71655974

InChI Key

WZHBYTVHUFURPY-UHFFFAOYSA-N

SMILES

O=C(C1=C(C2(N3C=CC=C(C3=NC2=O)C)CC1=O)N4CCCCC4)OCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 36.94 100
DMSO 36.94 100

Preparing Stock Solutions for SAK 3

The following data is based on the product molecular weight 369.41

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.54 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SAK 3

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SAK 3

For research use only

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