SAHM1
Tocris Bioscience, part of Bio-Techne | Catalog # 6477
Notch pathway inhibitor; prevents Notch complex assembly
Discontinued Product
6477 has been discontinued.
View all Notch Signaling Inhibitors products.
Key Product Details
Description
Notch pathway inhibitor; prevents Notch complex assembly
Product Description
SAHM1 is a notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Product Specifications
Molecular Weight
2196.58
Formula
C94H162N36O23S
Storage
Store at -20°C
Purity
≥90% (HPLC)
CAS Number
2050906-89-1
PubChem ID
137919859
InChI Key
ADWKVIAAKDSBNE-VHQDTIAVSA-N
SMILES
[H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)[C@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Bagheri Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields. J.Tissue Eng.Regen.Med. 2018 PMID: 28482141
- KleinJan The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J.Allergy Clin.Immunol. 2018 PMID: 29111218
- Ashley Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem 2015 PMID: 25914241
Product Specific Notices for SAHM1
For research use only
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