Sacubitril calcium
Tocris Bioscience, part of Bio-Techne | Catalog # 5772
Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Key Product Details
Description
Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Alternative Names
AHU 377
Product Description
Sacubitril calcium is a membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.Product Specifications
Molecular Weight
430.52
Formula
C24H28NO5.½Ca
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
CAS Number
1369773-39-6
PubChem ID
91827885
InChI Key
DDLCKLBRBPYKQS-OXXXZDCLSA-L
SMILES
[Ca++].C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.05 | 100 | |
| Ethanol | 8.61 | 20 |
Preparing Stock Solutions
for Sacubitril calcium
The following data is based on the product molecular weight 430.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.61 mL | 23.23 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.65 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ksander Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J.Med.Chem. 1995 PMID: 7752193
Product Specific Notices for Sacubitril calcium
For research use only
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