SA 4503 dihydrochloride

Name: SA 4503 dihydrochloride
Brand: Tocris Bioscience
SKU: 4951

Tocris Bioscience, part of Bio-Techne | Catalog # 4951

Citations (3)

COA / SDS

Selective σ1 receptor agonist

Key Product Details

Description:	Selective σ1 receptor agonist
Chemical Name:	1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	441.43

View Full Technical Details for SA 4503 dihydrochloride

Technical Data
Citations

Biological Activity for SA 4503 dihydrochloride

SA 4503 dihydrochloride is a selective σ1 receptor agonist (IC₅₀ = 17.4 nM). Exhibits selectivity for σ1 over σ2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.

Compound Libraries for SA 4503 dihydrochloride

SA 4503 dihydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SA 4503 dihydrochloride

M. Wt	441.43
Formula	C₂₃H₃₂N₂O₂.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	165377-44-6
PubChem ID	9954941
InChi Key	XWOXAKBQEMQMFH-UHFFFAOYSA-N
Smiles	COC1=C(OC)C=CC(CCN2CCN(CCCC3=CC=CC=C3)CC2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SA 4503 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	44.14	100
	DMSO	8.83	20

Preparing Stock Solutions for SA 4503 dihydrochloride

The following data is based on the product molecular weight 441.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.33 mL	22.65 mL
5 mM	0.45 mL	2.27 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for SA 4503 dihydrochloride

References are publications that support the biological activity of the product.

Lever σ1 and σ2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse 2006 PMID: 16463398
Matsuno Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur.J.Pharmacol. 1996 PMID: 8813641
Tagashira Stimulation of s1-receptor restores abnormal mitochondrial Ca²⁺ mobilization and ATP production following cardiac hypertrophy. Biochim.Biophys.Acta 2013 PMID: 23298811
Ruscher The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain 2011 PMID: 21278085