(S)-PFI 2 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5400
Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)
Key Product Details
Description
Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)
Product Description
(S)-PFI 2 hydrochloride is a negative control of (R)-PFI 2 hydrochloride. Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC50 = 1 μM) compared to the active enantiomer.Active Analog also available.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (R)-PFI 2 probe summary on the SGC website.Product Specifications
Molecular Weight
535.98
Formula
C23H25F4N3O3S.HCl
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
8-Fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride
CAS Number
1627607-88-8
PubChem ID
91691132
InChI Key
ZADKZNVAJGEFLC-BOXHHOBZSA-N
SMILES
O=C(N4CCCC4)[C@H](CC3=CC=CC(C(F)(F)F)=C3)NS(C2=CC1=C(C(F)=C2)CNCC1)(=O)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.6 | 100 | |
| Ethanol | 10.72 | 20 |
Preparing Stock Solutions
for (S)-PFI 2 hydrochloride
The following data is based on the product molecular weight 535.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.87 mL | 9.33 mL | 18.66 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.73 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.87 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Barsyte-Lovejoy (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc.Natl.Acad.Sci.U S A 2014 PMID: 25136132
Product Specific Notices for (S)-PFI 2 hydrochloride
For research use only
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