Ryanodine
Tocris Bioscience, part of Bio-Techne | Catalog # 1329
Ca2+ release inhibitor
Product Description
Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).Product Specifications
Molecular Weight
493.55
Formula
C25H35NO9
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
CAS Number
15662-33-6
PubChem ID
11317883
InChI Key
JJSYXNQGLHBRRK-SFEDZAPPSA-N
SMILES
O=C(C6=CC=CN6)O[C@@H]1[C@@]([C@@H](C)C)(O)[C@]4(C)[C@@]3(O)[C@@](O)1[C@]5(C)[C@@]2(O)CC[C@H](C)[C@@H](O)[C@@]23O[C@](O)4C5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.34 | 25 | |
| Ethanol | 4.94 | 10 |
Preparing Stock Solutions
for Ryanodine
The following data is based on the product molecular weight 493.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 8.10 mL | 40.52 mL | 81.05 mL |
| 1.25 mM | 1.62 mL | 8.10 mL | 16.21 mL |
| 2.5 mM | 0.81 mL | 4.05 mL | 8.10 mL |
| 12.5 mM | 0.16 mL | 0.81 mL | 1.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sutko Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle. Fed.Proc. 1985 PMID: 2415406
- Sutko The pharmacology of ryanodine and related compounds. Pharmacol.Rev. 1997 PMID: 9085309
- Bianchi Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle. Biochem.Pharmacol. 1997 PMID: 9174102
Product Specific Notices for Ryanodine
For research use only
Loading...
Loading...