Ryanodine

Name: Ryanodine
Brand: Tocris Bioscience
SKU: 1329

Tocris Bioscience, part of Bio-Techne | Catalog # 1329

Citations (237)

COA / SDS

Ca2+ release inhibitor

Key Product Details

Description:	Ca²⁺ release inhibitor
Chemical Name:	1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
Purity:	≥98% (HPLC)
Molecular Weight:	493.55

View Full Technical Details for Ryanodine

Technical Data
Citations

Biological Activity for Ryanodine

Ryanodine is a potent inhibitor of Ca²⁺ release from sarcoplasmic reticulum (IC₅₀ values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

Technical Data for Ryanodine

M. Wt	493.55
Formula	C₂₅H₃₅NO₉
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	15662-33-6
PubChem ID	11317883
InChi Key	JJSYXNQGLHBRRK-SFEDZAPPSA-N
Smiles	O=C(C6=CC=CN6)O[C@@H]1[C@@]([C@@H](C)C)(O)[C@]4(C)[C@@]3(O)[C@@](O)1[C@]5(C)[C@@]2(O)CC[C@H](C)[C@@H](O)[C@@]23O[C@](O)4C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ryanodine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	4.94	10
	DMSO	12.34	25

Preparing Stock Solutions for Ryanodine

The following data is based on the product molecular weight 493.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.10 mL	40.52 mL	81.05 mL
1.25 mM	1.62 mL	8.10 mL	16.21 mL
2.5 mM	0.81 mL	4.05 mL	8.10 mL
12.5 mM	0.16 mL	0.81 mL	1.62 mL

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References for Ryanodine

References are publications that support the biological activity of the product.

Sutko Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle. Fed.Proc. 1985 PMID: 2415406
Sutko The pharmacology of ryanodine and related compounds. Pharmacol.Rev. 1997 PMID: 9085309
Bianchi Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle. Biochem.Pharmacol. 1997 PMID: 9174102