RX 821002 hydrochloride

Name: RX 821002 hydrochloride
Brand: Tocris Bioscience
SKU: 1324

Catalog # 1324 | Tocris Bioscience a Bio-Techne Brand

Citations (7)

COA / SDS

Potent, selective α2D antagonist

Key Product Details

Description:	Potent, selective α_2D antagonist
Chemical Name:	2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	270.72

View Full Technical Details for RX 821002 hydrochloride

Technical Data
Citations (7) / Reviews

Biological Activity for RX 821002 hydrochloride

RX 821002 hydrochloride is a potent, selective α₂-adrenoceptor antagonist with very low affinity for imidazoline sites. Displays selectivity for the α_2D over the α_2A subtypes (pK_d values are 9.7 and 8.2 respectively).

Compound Libraries for RX 821002 hydrochloride

RX 821002 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RX 821002 hydrochloride

M. Wt	270.72
Formula	C₁₂H₁₄N₂O₃.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	109544-45-8
PubChem ID	11957683
InChi Key	IMPOOMVZVWKSAP-UHFFFAOYSA-N
Smiles	Cl.COC1(COC2=CC=CC=C2O1)C1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RX 821002 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		100
	DMSO	27.07	100

Preparing Stock Solutions for RX 821002 hydrochloride

The following data is based on the product molecular weight 270.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.47 mL	36.94 mL
5 mM	0.74 mL	3.69 mL	7.39 mL
10 mM	0.37 mL	1.85 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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Reconstitution Calculator

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References for RX 821002 hydrochloride

References are publications that support the biological activity of the product.

Trendelenburg Antagonists that differentiate between α_2A- and α_2D-adrenoceptors. Naunyn Schmiedebergs Arch.Pharmacol. 1996 PMID: 8692278
Erdbrugger Does [³H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [³H]rauwolscine? A comparison of nine tissues and cell lines. J.Pharmacol.Exp.Ther. 1995 PMID: 7791100
O'Rourke Characterisation of [³H]RX 821002 binding to alpha-2 adrenergic receptor subtypes. J.Pharmacol.Exp.Ther. 1994 PMID: 7908054

Citations for RX 821002 hydrochloride (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for RX 821002 hydrochloride include:

Uchański et al. (2019) An improved yeast surface display platform for the screening of nanobody immune libraries. Sci Rep. 9:382
PMID: 30674983
Staedtke et al. (2018) Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome. Nature. 564:273
PMID: 30542164
Li et al. (2017) Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat Med. 23:733
PMID: 28459438
Alves et al. (2014) Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats. J Chem Biol. 9:e83900
PMID: 24404141
Hott et al. (2012) Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear. Br J Pharmacol. 167:207
PMID: 22506532
Crestani et al. (2008) Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats. Br J Pharmacol. 153:583
PMID: 18037912
Deupree et al. (2008) Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipr. administration. BMC Pharmacol. 8:17
PMID: 18831759

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