RWJ 56110

Name: RWJ 56110
Brand: Tocris Bioscience
SKU: 2614

Tocris Bioscience, part of Bio-Techne | Catalog # 2614

Citations (29)

COA / SDS

Selective PAR1 antagonist

Discontinued Product

2614 has been discontinued. View all Protease-Activated Receptor Antagonists products.

Key Product Details

Description:	Selective PAR₁ antagonist
Chemical Name:	(αS)-N-[(1S)-3-Amino-1-[[(phenylmethyl)amino]carbonyl]propyl]-α-[[[[1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indol-6-yl]amino]carbonyl]amino]-3,4-difluoro-benzenepropanamide
Purity:	≥96% (HPLC)
Molecular Weight:	863.65

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Technical Data
Citations

Biological Activity for RWJ 56110

RWJ 56110 is a selective protease-activated receptor-1 (PAR₁) antagonist; displays no activity at PAR₂, PAR₃, or PAR₄ subtypes. Blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Also inhibits angiogenesis in a chick embryo angiogenesis model in vivo.

Technical Data for RWJ 56110

M. Wt	863.65
Formula	C₄₁H₄₃Cl₂F₂N₇O₃.2HCl
Storage	Store at -20°C
Purity	≥96% (HPLC)
CAS Number	2387505-58-8
PubChem ID	90488773
InChi Key	MGZSVSHDIOPSBO-ZEUUMAKDSA-N
Smiles	ClC1=CC=CC(Cl)=C1CN3C2=CC(NC(N[C@@H](CC5=CC(F)=C(F)C=C5)C(N[C@@H](CCN)C(NCC6=CC=CC=C6)=O)=O)=O)=CC=C2C(CN4CCCC4)=C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for RWJ 56110

References are publications that support the biological activity of the product.

Zania Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J.Pharmacol.Exp.Ther. 2006 PMID: 16595737
Andrade-Gordon Design, synthesis and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proc.Natl.Acad.Sci.USA 1999 PMID: 10535908
Maryanoff Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1). Curr.Med.Chem.Cardiovasc.Hematol.Agents 2003 PMID: 15317288

RWJ 56110

Tocris Bioscience, part of Bio-Techne | Catalog # 2614

Key Product Details

Biological Activity for RWJ 56110

Technical Data for RWJ 56110

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for RWJ 56110

Product Documents for RWJ 56110

COA

Certificate of Analysis

SDS

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