Ruthenium Red
Tocris Bioscience, part of Bio-Techne | Catalog # 1439
Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels
Key Product Details
Description
Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels
Product Description
Ruthenium Red blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.Product Specifications
Molecular Weight
786.35
Formula
H42N14O2Ru3Cl6
Storage
Store at RT
Chemical Name
Ammoniated ruthenium oxychloride
CAS Number
11103-72-3
PubChem ID
16218584
InChI Key
JQJSTVUROJELSR-UHFFFAOYSA-H
SMILES
[Ru+2]O[Ru+2]O[Ru+2].N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.86 | 10 |
Preparing Stock Solutions
for Ruthenium Red
The following data is based on the product molecular weight 786.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.72 mL | 63.58 mL | 127.17 mL |
| 0.5 mM | 2.54 mL | 12.72 mL | 25.43 mL |
| 1 mM | 1.27 mL | 6.36 mL | 12.72 mL |
| 5 mM | 0.25 mL | 1.27 mL | 2.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xu Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms. J.Biol.Chem. 1999 PMID: 10551824
- Bernardi Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red. Biochemistry 1984 PMID: 6202317
- Szallasi and Blumberg Vanilloid (capsaicin) receptors and mechanisms. Pharmacol.Rev. 1999 PMID: 10353985
- Amann and Maggi Ruthenium red as a capsaicin antagonist. Life Sci. 1991 PMID: 1715010
Product Specific Notices for Ruthenium Red
For research use only
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