Rufinamide

Name: Rufinamide
Brand: Tocris Bioscience
SKU: 3828

Tocris Bioscience, part of Bio-Techne | Catalog # 3828

Citations (3)

COA / SDS

Prolongs inactivation of sodium channels; anticonvulsant

Key Product Details

Description:	Prolongs inactivation of sodium channels; anticonvulsant
Alternative Names:	CGP 33101
Chemical Name:	1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	238.19

View Full Technical Details for Rufinamide

Technical Data
Citations

Biological Activity for Rufinamide

Rufinamide is a board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.

Technical Data for Rufinamide

M. Wt	238.19
Formula	C₁₀H₈F₂N₄O
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	106308-44-5
PubChem ID	129228
InChi Key	POGQSBRIGCQNEG-UHFFFAOYSA-N
Smiles	O=C(N)C1=CN(CC2=C(F)C=CC=C2F)N=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rufinamide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.82	100

Preparing Stock Solutions for Rufinamide

The following data is based on the product molecular weight 238.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.20 mL	20.99 mL	41.98 mL
5 mM	0.84 mL	4.20 mL	8.40 mL
10 mM	0.42 mL	2.10 mL	4.20 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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References for Rufinamide

References are publications that support the biological activity of the product.

Arroyo Rufinamide. Neurotherapeutics 2007 PMID: 17199032
White The anticonvulsant profile of rufin. (CGP 33101) in rodent seizure models. Epilepsia 2008 PMID: 18325020
Rogawski Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 2006 PMID: 16621450