(RS)-3,5-DHPG
Tocris Bioscience, part of Bio-Techne | Catalog # 0342
Selective group I mGlu agonist
Product Description
(RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5. Also reported to be an antagonist at metabotropic glutamate receptors linked to phospholipase D.S-enantiomer also available.
Product Specifications
Molecular Weight
183.16
Formula
C8H9NO4
Storage
Desiccate at -20°C
Purity
≥99% (HPLC)
Chemical Name
(RS)-3,5-Dihydroxyphenylglycine
CAS Number
146255-66-5
PubChem ID
108001
InChI Key
HOOWCUZPEFNHDT-UHFFFAOYSA-N
SMILES
NC(C(O)=O)C1=CC(O)=CC(O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.83 | 10 |
Preparing Stock Solutions
for (RS)-3,5-DHPG
The following data is based on the product molecular weight 183.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 54.60 mL | 272.99 mL | 545.97 mL |
| 0.5 mM | 10.92 mL | 54.60 mL | 109.19 mL |
| 1 mM | 5.46 mL | 27.30 mL | 54.60 mL |
| 5 mM | 1.09 mL | 5.46 mL | 10.92 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Palmer The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology 1997 PMID: 9517422
- Mistry Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II-selective metabotropic glutamate receptor agonists. Br.J.Pharmacol. 1998 PMID: 9504400
- Pellegrini-Giampietro Pharmacological characterization of metabotropic glutamate recpetors coupled to phopholipase D in the rat hippocampus. Br.J.Pharmacol. 1996 PMID: 8799579
- Ito 3,5-Dihydroxyphenylglycine: a potent agonist of metabotropic glutamate receptors. NeuroReport 1992 PMID: 1362358
Product Specific Notices for (RS)-3,5-DHPG
For research use only
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