Rp-8-Br-PET-cGMPS
Tocris Bioscience, part of Bio-Techne | Catalog # 3028
Protein kinase G inhibitor
Product Description
Rp-8-Br-PET-cGMPS is a competitive, reversible cGMP-dependent protein kinase (PKG) inhibitor; cGMP analog.This product is sold in units of 560μg, equivalent to 1μmol.
Product Specifications
Molecular Weight
562.27
Formula
C18H14BrN5NaO6PS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Bromo-3,4-dihydro-3-[3,5-O-[(R)-mercaptophosphinylidene]-β-D-ribofuranosyl]-6-phenyl-9H-Imidazo[1,2-a]purin-9-one sodium salt
CAS Number
185246-32-6
PubChem ID
23695925
InChI Key
PNUXBFRWMZKKAJ-IPZAVTHYSA-M
SMILES
[H][C@@]([C@@](O[C@@H](N3C(Br)=NC5=C3NC4=NC(C6=CC=CC=C6)=CN4C5=O)[C@@H]2O)([H])CO1)2O[P@@]1(S[Na])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.25 | 20 | |
| DMSO | 22.49 | 40 |
Preparing Stock Solutions
for Rp-8-Br-PET-cGMPS
The following data is based on the product molecular weight 562.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.4 mM | 4.45 mL | 22.23 mL | 44.46 mL |
| 2 mM | 0.89 mL | 4.45 mL | 8.89 mL |
| 4 mM | 0.44 mL | 2.22 mL | 4.45 mL |
| 20 mM | 0.09 mL | 0.44 mL | 0.89 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Qi Protein kinase G regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins. Br.J.Pharmacol. 2007 PMID: 17891157
- Valtcheva The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells. J.Biol.Chem. 2008 PMID: 19008225
- Wei Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry 1996 PMID: 8988020
Product Specific Notices for Rp-8-Br-PET-cGMPS
For research use only
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