Rosuvastatin calcium
Tocris Bioscience, part of Bio-Techne | Catalog # 6343
Potent HMG-CoA reductase inhibitor
Key Product Details
Description
Potent HMG-CoA reductase inhibitor
Product Description
Rosuvastatin calcium is a potent HMG-CoA reductase inhibitor (IC50 = 5.4 nM). Inhibits cholesterol synthesis in rat hepatocytes in vitro and in vivo. Reduces plasma LDL cholesterol levels. Enhances lentiviral transduction of natural killer cells. Orally bioavailable.Product Specifications
Molecular Weight
500.57
Formula
C22H27FN3O6S.½Ca
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl])-3,5-dihydroxyhept-6-enoic acid hemicalcium salt
CAS Number
147098-20-2
PubChem ID
5282455
InChI Key
LALFOYNTGMUKGG-BGRFNVSISA-L
SMILES
CC(C1=C(C(C2=CC=C(F)C=C2)=NC(N(S(C)(=O)=O)C)=N1)/C=C/[C@@H](O)C[C@@H](O)CC(O[Ca]OC(C[C@H](O)C[C@H](O)/C=C/C(C(C3=CC=C(F)C=C3)=NC(N(S(C)(=O)=O)C)=N4)=C4C(C)C)=O)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.06 | 100 |
Preparing Stock Solutions
for Rosuvastatin calcium
The following data is based on the product molecular weight 500.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.00 mL | 9.99 mL | 19.98 mL |
| 5 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 10 mM | 0.20 mL | 1.00 mL | 2.00 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gong Rosuvastatin enhances VSV-G lentiviral transduction of NK cells via upregulation of the low-density lipoprotein receptor. Mol.Ther.Methods Clin.Dev. 2020 PMID: 32300610
- McTaggart Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am.J.Cardiol. 2001 PMID: 11256847
Product Specific Notices for Rosuvastatin calcium
For research use only
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