Rosiglitazone

Tocris Bioscience, part of Bio-Techne | Catalog # 5325

Potent and selective PPARγ agonist; antidiabetic agent
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Key Product Details

Description

Potent and selective PPARγ agonist; antidiabetic agent

Alternative Names

BRL 49653

View all PPAR gamma Receptor Agonists »

Product Description

Rosiglitazone is a potent and selective PPARγ agonist (EC50 = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Also promotes differentiation of urothelial organoids in combination with Erlotinib (Cat. No. 7194). Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

Product Specifications

Molecular Weight

357.43

Formula

C18H19N3O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

CAS Number

122320-73-4

PubChem ID

77999

InChI Key

YASAKCUCGLMORW-UHFFFAOYSA-N

SMILES

CN(CCOC1=CC=C(CC2SC(NC2=O)=O)C=C1)C3=CC=CC=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.74 100

Preparing Stock Solutions for Rosiglitazone

The following data is based on the product molecular weight 357.43

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.80 mL 13.99 mL 27.98 mL
5 mM 0.56 mL 2.80 mL 5.60 mL
10 mM 0.28 mL 1.40 mL 2.80 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Product Documents for Rosiglitazone

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Rosiglitazone

For research use only

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