Ro 48-8071 fumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 5389
2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
Key Product Details
Description
2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
Product Description
Ro 48-8071 fumarate is a 2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).Product Specifications
Molecular Weight
564.44
Formula
C23H27BrFNO2.C4H4O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone
CAS Number
189197-69-1
PubChem ID
9959583
InChI Key
XCYAYLWZCRGKDS-WLHGVMLRSA-N
SMILES
FC1=C(C(C2=CC=C(Br)C=C2)=O)C=CC(OCCCCCCN(C)CC=C)=C1.OC(/C=C/C(O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.29 | 20 with gentle warming | |
| DMSO | 56.44 | 100 |
Preparing Stock Solutions
for Ro 48-8071 fumarate
The following data is based on the product molecular weight 564.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.77 mL | 8.86 mL | 17.72 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.77 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Grinter An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 2011 PMID: 21315634
- Shoemaker Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 2013 PMID: 23441171
- Morand Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to SimV.. J.Lipid.Res. 1997 PMID: 9162756
Product Specific Notices for Ro 48-8071 fumarate
For research use only
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