Ro 48-8071 fumarate

Name: Ro 48-8071 fumarate
Brand: Tocris Bioscience
SKU: 5389

Tocris Bioscience, part of Bio-Techne | Catalog # 5389

Citations (2)

COA / SDS

2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis

Key Product Details

Description:	2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
Chemical Name:	(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone
Purity:	≥98% (HPLC)
Molecular Weight:	564.44

View Full Technical Details for Ro 48-8071 fumarate

Technical Data
Citations

Biological Activity for Ro 48-8071 fumarate

Ro 48-8071 fumarate is a 2,3-Oxidosqualene cyclase (OSC) inhibitor (IC₅₀ = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC₅₀ = 1.74 μM).

Compound Libraries for Ro 48-8071 fumarate

Ro 48-8071 fumarate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Ro 48-8071 fumarate

M. Wt	564.44
Formula	C₂₃H₂₇BrFNO₂.C₄H₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	189197-69-1
PubChem ID	9959583
InChi Key	XCYAYLWZCRGKDS-WLHGVMLRSA-N
Smiles	FC1=C(C(C2=CC=C(Br)C=C2)=O)C=CC(OCCCCCCN(C)CC=C)=C1.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 48-8071 fumarate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	11.29	20 with gentle warming
	DMSO	56.44	100

Preparing Stock Solutions for Ro 48-8071 fumarate

The following data is based on the product molecular weight 564.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.77 mL	8.86 mL	17.72 mL
5 mM	0.35 mL	1.77 mL	3.54 mL
10 mM	0.18 mL	0.89 mL	1.77 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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References for Ro 48-8071 fumarate

References are publications that support the biological activity of the product.

Grinter An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 2011 PMID: 21315634
Shoemaker Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 2013 PMID: 23441171
Morand Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to SimV.. J.Lipid.Res. 1997 PMID: 9162756