Ro 15-4513
Tocris Bioscience, part of Bio-Techne | Catalog # 1997
Benzodiazepine partial inverse agonist
Key Product Details
Description
Benzodiazepine partial inverse agonist
Product Description
Ro 15-4513 is a high affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.Product Specifications
Molecular Weight
326.31
Formula
C15H14N6O3
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
CAS Number
91917-65-6
PubChem ID
5081
InChI Key
CFSOJZTUTOQNIA-UHFFFAOYSA-N
SMILES
CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(=C3)N=[N+]=[N-])N2C=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.26 | 10 | |
| Ethanol | 1.63 | 5 |
Preparing Stock Solutions
for Ro 15-4513
The following data is based on the product molecular weight 326.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.65 mL | 153.23 mL | 306.46 mL |
| 0.5 mM | 6.13 mL | 30.65 mL | 61.29 mL |
| 1 mM | 3.06 mL | 15.32 mL | 30.65 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.13 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wong and Skolnick High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 1992 PMID: 1311690
- Knoflach Pharmacological modulation of the D.pam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol.Pharmacol. 1996 PMID: 8913357
- Suzdak A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 1986 PMID: 3022383
Product Specific Notices for Ro 15-4513
For research use only
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