Ro 08-2750

Name: Ro 08-2750
Brand: Tocris Bioscience
SKU: 2272

Tocris Bioscience, part of Bio-Techne | Catalog # 2272

Citations (18)

COA / SDS

Inhibits NGF binding to p75NTR and TrkA

Key Product Details

Description:	Inhibits NGF binding to p75^NTR and TrkA
Chemical Name:	2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
Purity:	≥95% (HPLC)
Molecular Weight:	270.24

View Full Technical Details for Ro 08-2750

Technical Data
Citations

Biological Activity for Ro 08-2750

Ro 08-2750 is a non-peptide inhibitor of NGF that binds the NGF dimer (K_D ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75^NTR at submicromolar concentrations, and to both p75^NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation.

Technical Data for Ro 08-2750

M. Wt	270.24
Formula	C₁₃H₁₀N₄O₃
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	37854-59-4
PubChem ID	17756791
InChi Key	JDEMVNYMYPJJIM-UHFFFAOYSA-N
Smiles	CN1C2=CC(C=O)=C(C)C=C2N=C2C(=O)NC(=O)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 08-2750

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.7	10 with gentle warming

Preparing Stock Solutions for Ro 08-2750

The following data is based on the product molecular weight 270.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.00 mL	185.02 mL	370.04 mL
0.5 mM	7.40 mL	37.00 mL	74.01 mL
1 mM	3.70 mL	18.50 mL	37.00 mL
5 mM	0.74 mL	3.70 mL	7.40 mL

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References for Ro 08-2750

References are publications that support the biological activity of the product.

Arkin and Wells Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat.Rev.Drug Discov. 2004 PMID: 15060526
Yang NTRK1 is a positive regulator of YAP oncogenic function. Oncogene 2018 PMID: 30542115
Niederhauser NGF ligand alters NGF signaling via p75NTR and TrkA. J.Neurosci.Res. 2000 PMID: 10900073