Ro 04-5595 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2005

GluN2B-selective NMDA antagonist
Discontinued Product
2005 has been discontinued. View all NMDA Receptor Antagonists products.

Key Product Details

Description

GluN2B-selective NMDA antagonist

View all NMDA Receptor Antagonists »

Product Description

Ro 04-5595 hydrochloride is a selective antagonist for GluN2B (formally NR2B) containing NMDA receptors (Ki = 31 nM).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications

Molecular Weight

368.30

Formula

C19H22ClNO2.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[2-(4-Chlorophenyl)ethyl]-1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinol hydrochloride

CAS Number

64047-73-0

PubChem ID

46739

InChI Key

NVIPBLQAFKRFSZ-UHFFFAOYSA-N

SMILES

Cl.COC1=CC2=C(C=C1O)C(CCC1=CC=C(Cl)C=C1)N(C)CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5.52 15
DMSO 36.83 100

Preparing Stock Solutions for Ro 04-5595 hydrochloride

The following data is based on the product molecular weight 368.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.58 mL 27.15 mL
5 mM 0.54 mL 2.72 mL 5.43 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

  • Mutel In vitro binding properties in rat brain of [3H] Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J.Neurochem.

Product Documents for Ro 04-5595 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ro 04-5595 hydrochloride

For research use only

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