RNB 61

Name: RNB 61
Brand: Tocris Bioscience
SKU: 8835

Tocris Bioscience, part of Bio-Techne | Catalog # 8835

COA / SDS

Highly potent and selective CB2R agonist

Key Product Details

Description:	Highly potent and selective CB2R agonist
Chemical Name:	N-[(3E)-5-tert-Butyl-2-(cyclobutylmethyl)-1-methyl-1,2-dihydro-3H-pyrazol-3-ylidene]-2-(2-hydroxy-2-methylpropoxy)-5-(trifluoromethyl)benzamide
Purity:	≥97% (HPLC)
Molecular Weight:	481.56

View Full Technical Details for RNB 61

Technical Data
Citations

Biological Activity for RNB 61

RNB 61 is a highly potent and selective cannabinoid CB2 receptor (CB2R) agonist (Ki = 0.57 nM). RNB 61 shows >5000-fold selectivity for hCB2R over hCB1R. In vivo, RNB 61 inhibits the FSK-induced cAMP formation on mouse, rat, and dog CB2Rs (EC₅₀ values ranging from 0.13 to 1.86 nM). RNB 61 has a a peripherally restricted action and exerts a nephroprotective and/or antifibrotic effects in animal models of kidney disease.

Technical Data for RNB 61

M. Wt	481.56
Formula	C₂₅H₃₄F₃N₃O₃
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1217403-51-4
PubChem ID	66642909
InChi Key	SHUYRGCUYVGFJV-XHLNEMQHSA-N
Smiles	O=C(C1=C(C=CC(C(F)(F)F)=C1)OCC(C)(O)C)/N=C2N(N(C(C(C)(C)C)=C/2)C)CC3CCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RNB 61

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.08	50
	ethanol	48.16	100

Preparing Stock Solutions for RNB 61

The following data is based on the product molecular weight 481.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.38 mL	20.77 mL
5 mM	0.42 mL	2.08 mL	4.15 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for RNB 61

References are publications that support the biological activity of the product.

Chicca A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor- selective full agonist for in vivo studies. ACS Pharmacol.Transl.Sci. 2024 PMID: 39144568