RNB 61
Tocris Bioscience, part of Bio-Techne | Catalog # 8835
Highly potent and selective CB2R agonist
Key Product Details
Description
Highly potent and selective CB2R agonist
Product Description
RNB 61 is a highly potent and selective cannabinoid CB2 receptor (CB2R) agonist (Ki = 0.57 nM). RNB 61 shows >5000-fold selectivity for hCB2R over hCB1R. In vivo, RNB 61 inhibits the FSK-induced cAMP formation on mouse, rat, and dog CB2Rs (EC50 values ranging from 0.13 to 1.86 nM). RNB 61 has a a peripherally restricted action and exerts a nephroprotective and/or antifibrotic effects in animal models of kidney disease.Product Specifications
Molecular Weight
481.56
Formula
C25H34F3N3O3
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
N-[(3E)-5-tert-Butyl-2-(cyclobutylmethyl)-1-methyl-1,2-dihydro-3H-pyrazol-3-ylidene]-2-(2-hydroxy-2-methylpropoxy)-5-(trifluoromethyl)benzamide
CAS Number
1217403-51-4
PubChem ID
66642909
InChI Key
SHUYRGCUYVGFJV-XHLNEMQHSA-N
SMILES
O=C(C1=C(C=CC(C(F)(F)F)=C1)OCC(C)(O)C)/N=C2N(N(C(C(C)(C)C)=C/2)C)CC3CCC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.08 | 50 | |
| Ethanol | 48.16 | 100 |
Preparing Stock Solutions
for RNB 61
The following data is based on the product molecular weight 481.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.08 mL | 10.38 mL | 20.77 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.15 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.08 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chicca A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor- selective full agonist for in vivo studies. ACS Pharmacol.Transl.Sci. 2024 PMID: 39144568
Product Specific Notices for RNB 61
For research use only
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