RN 9893 hydrochloride

Name: RN 9893 hydrochloride
Brand: Tocris Bioscience
SKU: 5678

Tocris Bioscience, part of Bio-Techne | Catalog # 5678

Citations (2)

COA / SDS

Potent and selective TRPV4 antagonist

Key Product Details

Description:	Potent and selective TRPV4 antagonist
Chemical Name:	N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	536.95

View Full Technical Details for RN 9893 hydrochloride

Technical Data
Citations

Biological Activity for RN 9893 hydrochloride

RN 9893 hydrochloride is a potent and selective TRPV4 antagonist (IC₅₀ values are 320, 420 and 660 nM for mouse, human and rat channels, respectively). Exhibits >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Orally bioavailable.

Compound Libraries for RN 9893 hydrochloride

RN 9893 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RN 9893 hydrochloride

M. Wt	536.95
Formula	C₂₁H₂₃F₃N₄O₅S.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	2109450-40-8
PubChem ID	121513879
InChi Key	ULUOUAGDTULBRZ-UHFFFAOYSA-N
Smiles	O=C(NC2=CC=C(S(N3CCN(C(C)C)CC3)(=O)=O)C=C2)C1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RN 9893 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.69	100

Preparing Stock Solutions for RN 9893 hydrochloride

The following data is based on the product molecular weight 536.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.31 mL	18.62 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for RN 9893 hydrochloride

References are publications that support the biological activity of the product.

Wei Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg.Med.Chem.Lett. 2015 PMID: 26235950