RN 9893 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5678
Potent and selective TRPV4 antagonist
Product Description
RN 9893 hydrochloride is a potent and selective TRPV4 antagonist (IC50 values are 320, 420 and 660 nM for mouse, human and rat channels, respectively). Exhibits >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Orally bioavailable.Product Specifications
Molecular Weight
536.95
Formula
C21H23F3N4O5S.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride
CAS Number
2109450-40-8
PubChem ID
121513879
InChI Key
ULUOUAGDTULBRZ-UHFFFAOYSA-N
SMILES
O=C(NC2=CC=C(S(N3CCN(C(C)C)CC3)(=O)=O)C=C2)C1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.69 | 100 |
Preparing Stock Solutions
for RN 9893 hydrochloride
The following data is based on the product molecular weight 536.95
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.86 mL | 9.31 mL | 18.62 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.72 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.86 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wei Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg.Med.Chem.Lett. 2015 PMID: 26235950
Product Specific Notices for RN 9893 hydrochloride
For research use only
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