Rivastigmine tartrate
Tocris Bioscience, part of Bio-Techne | Catalog # 4440
Dual AChE and BChE inhibitor
Key Product Details
Description
Dual AChE and BChE inhibitor
Alternative Names
ENA 713
Product Description
Rivastigmine tartrate is a cholinesterase inhibitor; inhibits both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 ranges are 4.3-4760 nM and 16-238 nM respectively). Rivastigmine increases α-secretase activity and directs APP processing to the non-amyloidogenic pathway. Brain penetrant.Product Specifications
Molecular Weight
400.42
Formula
C14H22N2O2.C4H6O6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester (2R,3R)-2,3-dihydroxybutanedioate
CAS Number
129101-54-8
PubChem ID
6918078
InChI Key
GWHQHAUAXRMMOT-MBANBULQSA-N
SMILES
O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 40.04 | 100 | |
| DMSO | 40.04 | 100 |
Preparing Stock Solutions
for Rivastigmine tartrate
The following data is based on the product molecular weight 400.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.49 mL | 24.97 mL |
| 5 mM | 0.50 mL | 2.50 mL | 4.99 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brus J.Med.Chem.
- Bailey Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 2011 PMID: 21799757
- Luo Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 2006 PMID: 16570913
- Mehta New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis 2012 PMID: 22216416
- Groner The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 2007 PMID: 17347320
Product Specific Notices for Rivastigmine tartrate
For research use only
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