Ritanserin
Tocris Bioscience, part of Bio-Techne | Catalog # 1955
Potent 5-HT2 antagonist
Key Product Details
Description
Potent 5-HT2 antagonist
Product Description
Ritanserin is a potent and long-acting 5-HT2 receptor antagonist (Ki = 0.39 nM). Anxiolytic in vivo.Product Specifications
Molecular Weight
477.57
Formula
C27H25F2N3OS
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-[2-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
CAS Number
87051-43-2
PubChem ID
5074
InChI Key
JUQLTPCYUFPYKE-UHFFFAOYSA-N
SMILES
O=C1N3C(SC=C3)=NC(C)=C1CCN4CC/C(CC4)=C(C5=CC=C(F)C=C5)/C2=CC=C(F)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.76 | 100 | |
| Ethanol | 11.94 | 25 |
Preparing Stock Solutions
for Ritanserin
The following data is based on the product molecular weight 477.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.47 mL | 20.94 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.19 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Leysen Receptor-binding properties in vitro and in vivo of ritanserin. Mol.Pharmacol. 1985 PMID: 2860558
- Watanabe Syntheses and 5-HT2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivatives. J.Med.Chem. 1992 PMID: 1732528
- Janssen Pharmacology of potent and selective S2-serotonergic antagonists. J.Cardiovasc.Pharmacol. 1985 PMID: 2412048
Product Specific Notices for Ritanserin
For research use only
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