Risperidone

Name: Risperidone
Brand: Tocris Bioscience
SKU: 2865
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2865

(1)

Citations (39)

COA / SDS

5-HT2A antagonist; also D2 antagonist; atypical antipsychotic

Key Product Details

Description:	5-HT_2A antagonist; also D₂ antagonist; atypical antipsychotic
Alternative Names:	R 64 766
Chemical Name:	3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	410.48

View Full Technical Details for Risperidone

Technical Data
Citations / Reviews (1)

Biological Activity for Risperidone

Risperidone is an atypical antipsychotic agent that displays 5-HT_2A receptor antagonism. Also displays high affinity at D₂ receptors (K_i values are 0.4 and 3.13 nM for 5-HT_2A and D₂ receptors respectively).

Technical Data for Risperidone

M. Wt	410.48
Formula	C₂₃H₂₇FN₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	106266-06-2
PubChem ID	5073
InChi Key	RAPZEAPATHNIPO-UHFFFAOYSA-N
Smiles	FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(CCCC5)N5C4=O)CC3)=NO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Risperidone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.1	10
	ethanol	4.1	10

Preparing Stock Solutions for Risperidone

The following data is based on the product molecular weight 410.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.36 mL	121.81 mL	243.62 mL
0.5 mM	4.87 mL	24.36 mL	48.72 mL
1 mM	2.44 mL	12.18 mL	24.36 mL
5 mM	0.49 mL	2.44 mL	4.87 mL

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Reconstitution Calculator

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References for Risperidone

References are publications that support the biological activity of the product.

Wang Structure of the D₂ DA receptor bound to the atypical antipsychotic drug risperidone Nature 2018 PMID: 29466326
Leysen Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 1994 PMID: 7520908
Stathis Risperidone: a novel antipsychotic with many "atypical" properties. Psychopharmacol.
Leysen Biochemical profile of risperidone, a new antipsychotic. J.Pharmacol.Exp.Ther. 1988 PMID: 2460616