RG 108

Name: RG 108
Brand: Tocris Bioscience
SKU: 3295
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3295

(2)

Citations (25)

COA / SDS

Non-nucleoside DNA methyltransferase inhibitor

Key Product Details

Description:	Non-nucleoside DNA methyltransferase inhibitor
Chemical Name:	N-Phthalyl-L-tryptophan
Purity:	≥98% (HPLC)
Molecular Weight:	334.33

View Full Technical Details for RG 108

Technical Data
Citations / Reviews (2)

Biological Activity for RG 108

RG 108 is a non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.

Compound Libraries for RG 108

RG 108 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for RG 108

M. Wt	334.33
Formula	C₁₉H₁₄N₂O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	48208-26-0
PubChem ID	702558
InChi Key	HPTXLHAHLXOAKV-INIZCTEOSA-N
Smiles	O=C(C(C=CC=C4)=C4C3=O)N3[C@H](C(O)=O)CC2=CNC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RG 108

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.43	100
	ethanol	33.43	100

Preparing Stock Solutions for RG 108

The following data is based on the product molecular weight 334.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.99 mL	14.96 mL	29.91 mL
5 mM	0.60 mL	2.99 mL	5.98 mL
10 mM	0.30 mL	1.50 mL	2.99 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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Reconstitution Calculator

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References for RG 108

References are publications that support the biological activity of the product.

Stresemann Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 2006 PMID: 16510601
Schirrmacher Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases. Bioconjug.Chem. 2006 PMID: 16536454
Brueckner Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of DNA methyltransferase. Cancer Res. 2005 PMID: 16024632