Reversan

Name: Reversan
Brand: Tocris Bioscience
SKU: 3722

Tocris Bioscience, part of Bio-Techne | Catalog # 3722

Citations (11)

COA / SDS

Selective MRP1 and P-gp inhibitor

Key Product Details

Description:	Selective MRP1 and P-gp inhibitor
Chemical Name:	N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	441.52

View Full Technical Details for Reversan

Technical Data
Citations

Biological Activity for Reversan

Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

Compound Libraries for Reversan

Reversan is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Reversan

M. Wt	441.52
Formula	C₂₆H₂₇N₅O₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	313397-13-6
PubChem ID	2298706
InChi Key	JTRXWCLQFAZHGP-UHFFFAOYSA-N
Smiles	O=C(NCCCN5CCOCC5)C2=C1N=C(C4=CC=CC=C4)C=C(C3=CC=CC=C3)N1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Reversan

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.83	20

Preparing Stock Solutions for Reversan

The following data is based on the product molecular weight 441.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.32 mL	56.62 mL	113.25 mL
1 mM	2.26 mL	11.32 mL	22.65 mL
2 mM	1.13 mL	5.66 mL	11.32 mL
10 mM	0.23 mL	1.13 mL	2.26 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Reversan

References are publications that support the biological activity of the product.

Burkhart Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 2009 PMID: 19654298