Rauwolscine hydrochloride is a standard α₂-adrenergic antagonist (K_i values are 3.5, 4.6, and 0.6 nM at cloned human α_2A, α_2B, and α_2C-adrenoceptors respectively). Partial agonist at 5-HT_1A receptors.

Diastereomer also avilable.

Product Specifications

Molecular Weight

390.91

Formula

C₂₁H₂₆N₂O₃.HCl

Storage

Store at RT

Purity

≥95% (HPLC)

Chemical Name

17α-Hydroxy-20α-yohimban-16β-carboxylic acid,methyl ester hydrochloride

CAS Number

6211-32-1

PubChem ID

197067

InChI Key

PIPZGJSEDRMUAW-ZKKXXTDSSA-N

SMILES

[H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@]3([H])[C@]([C@H]([C@](OC)=O)[C@@H](O)CC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		5 with gentle warming
	DMSO	9.77	25 with gentle warming

Preparing Stock Solutions for Rauwolscine hydrochloride

The following data is based on the product molecular weight 390.91

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.23 mL	51.16 mL	102.33 mL
1.25 mM	2.05 mL	10.23 mL	20.47 mL
2.5 mM	1.02 mL	5.12 mL	10.23 mL
12.5 mM	0.20 mL	1.02 mL	2.05 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Hieble β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 1995 PMID: 7658428
Uhlen [3H]RS79948-197 binding to human, rat, guinea pig and pig α_2A-, α_2B-, and α_2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 1998 PMID: 9551719
Arthur Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT_1A receptors. Biochem.Pharmacol. 1993 PMID: 8517875

Rauwolscine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 0891

Key Product Details

Description

Alternative Names

View all Adrenergic alpha-2 Receptor Antagonists »

Product Description