rac-CCT 250863
Tocris Bioscience, part of Bio-Techne | Catalog # 4546
Potent Nek2 inhibitor
Product Description
rac-CCT 250863 is a potent Nek2 inhibitor (IC50 = 73 nM). Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.Product Specifications
Molecular Weight
490.54
Formula
C24H25F3N4O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[2-Amino-5-[4-[(dimethylamino)methyl]-2-thienyl]-3-pyridinyl]-2-[[(2Z)-4,4,4-trifluoro-1-methyl-2-buten-1-yl]oxy]benzamide
CAS Number
1364269-06-6
PubChem ID
57386035
InChI Key
LLEOOSLUHRQCHZ-SREVYHEPSA-N
SMILES
CN(C)CC1=CSC(C2=CN=C(N)C(C3=CC(OC(/C=C\C(F)(F)F)C)=C(C(N)=O)C=C3)=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 49.05 | 100 | |
| DMSO | 49.05 | 100 |
Preparing Stock Solutions
for rac-CCT 250863
The following data is based on the product molecular weight 490.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.19 mL | 20.39 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Innocenti Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J.Med.Chem. 2012 PMID: 22404346
Product Specific Notices for rac-CCT 250863
For research use only
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