rac-CCT 250863

Name: rac-CCT 250863
Brand: Tocris Bioscience
SKU: 4546

Tocris Bioscience, part of Bio-Techne | Catalog # 4546

Citations (3)

COA / SDS

Potent Nek2 inhibitor

Key Product Details

Description:	Potent Nek2 inhibitor
Chemical Name:	4-[2-Amino-5-[4-[(dimethylamino)methyl]-2-thienyl]-3-pyridinyl]-2-[[(2Z)-4,4,4-trifluoro-1-methyl-2-buten-1-yl]oxy]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	490.54

View Full Technical Details for rac-CCT 250863

Technical Data
Citations

Biological Activity for rac-CCT 250863

rac-CCT 250863 is a potent Nek2 inhibitor (IC₅₀ = 73 nM). Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.

Technical Data for rac-CCT 250863

M. Wt	490.54
Formula	C₂₄H₂₅F₃N₄O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1364269-06-6
PubChem ID	57386035
InChi Key	LLEOOSLUHRQCHZ-SREVYHEPSA-N
Smiles	CN(C)CC1=CSC(C2=CN=C(N)C(C3=CC(OC(/C=C\C(F)(F)F)C)=C(C(N)=O)C=C3)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for rac-CCT 250863

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	49.05	100
	DMSO	49.05	100

Preparing Stock Solutions for rac-CCT 250863

The following data is based on the product molecular weight 490.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.19 mL	20.39 mL
5 mM	0.41 mL	2.04 mL	4.08 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for rac-CCT 250863

References are publications that support the biological activity of the product.

Innocenti Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J.Med.Chem. 2012 PMID: 22404346