R-96544 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1742

Potent, selective 5-HT2A antagonist
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Key Product Details

Description

Potent, selective 5-HT2A antagonist

View all 5-HT2A Receptor Antagonists »

Product Description

R-96544 hydrochloride is a potent, selective 5-HT2 receptor antagonist; displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM). IC50 values are 2.2, 310, 2400, 3700, > 5000 and > 5000 nM for 5-HT2, α1-adrenergic, D2 dopamine, 5-HT1, 5-HT3 and β-adrenergic receptors respectively. Inhibits 5-HT-induced platelet aggregation and pressor responses in vivo.

Product Specifications

Molecular Weight

391.94

Formula

C22H29NO3.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(2R,4R)-5-[2-[2-[2-(3-Methoxyphenyl)ethyl]phenoxy]ethyl]-1-methyl-3-pyrrolidinol hydrochloride

CAS Number

167144-80-1

PubChem ID

10668210

InChI Key

OUKRSTJUAQEATQ-GZJHNZOKSA-N

SMILES

Cl[H].COC1=CC=CC(CCC2=C(OCC[C@@H]3C[C@@H](O)CN3C)C=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 39.19 100
DMSO 39.19 100

Preparing Stock Solutions for R-96544 hydrochloride

The following data is based on the product molecular weight 391.94

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.76 mL 25.51 mL
5 mM 0.51 mL 2.55 mL 5.10 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Product Documents for R-96544 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for R-96544 hydrochloride

For research use only

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