Quin C1
Tocris Bioscience, part of Bio-Techne | Catalog # 5583
Potent and selective FPR2 agonist
Key Product Details
Description
Potent and selective FPR2 agonist
Product Description
Quin C1 is a potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.Product Specifications
Molecular Weight
445.51
Formula
C26H27N3O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Butoxy-N-[1,4-dihydro-2-(4-methoxyphenyl)-4-oxo-3(2H)-quinazolinyl]benzamide
CAS Number
786706-21-6
PubChem ID
11751175
InChI Key
XORVAHQXRDLSFT-UHFFFAOYSA-N
SMILES
O=C1N(NC(C2=CC=C(OCCCC)C=C2)=O)C(C3=CC=C(OC)C=C3)NC4=CC=CC=C41
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.55 | 100 |
Preparing Stock Solutions
for Quin C1
The following data is based on the product molecular weight 445.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.22 mL | 22.45 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Corminboeuf FPR2/ALXR agonists and the resolution of inflammation. J.Med.Chem. 2014 PMID: 25365541
- Zhou Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 2007 PMID: 17652444
Product Specific Notices for Quin C1
For research use only
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