PZ 3022
Tocris Bioscience, part of Bio-Techne | Catalog # 7876
PanK Activator
Product Description
PZ 3022 is a potent allosteric pantothenate kinase (PanK) activator (EC50=5.3 nM for PanK3). In a mouse model of propionic acidemia, treatment with PZ 3022 increases hepatic CoASH and C2-CoA, and decreases C3-CoA, improving intracellular C3:C2-CoA ratio and plasma C3:C2-carnitine ratios. PZ 3022 is orally bioavailable.Licensing Information
Sold under license from St. Jude Children's Research HospitalProduct Specifications
Molecular Weight
347.42
Formula
C20H21N5O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-[4-[2-(4-Cyclopropylphenyl)acetyl]-1-piperazinyl]-3-pyridazinecarbonitrile
CAS Number
2170608-85-0
PubChem ID
132261124
InChI Key
CXSADKGUEBUMLH-UHFFFAOYSA-N
SMILES
N#CC1=NN=C(N2CCN(CC2)C(CC3=CC=C(C4CC4)C=C3)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.74 | 100 |
Preparing Stock Solutions
for PZ 3022
The following data is based on the product molecular weight 347.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.88 mL | 14.39 mL | 28.78 mL |
| 5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Subramanian Pantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia. Sci.Transl.Med. 2021 PMID: 34524863
Product Specific Notices for PZ 3022
For research use only
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