PZ 3022

Name: PZ 3022
Brand: Tocris Bioscience
SKU: 7876

Tocris Bioscience, part of Bio-Techne | Catalog # 7876

COA / SDS

PanK Activator

Key Product Details

Description:	PanK Activator
Chemical Name:	6-[4-[2-(4-Cyclopropylphenyl)acetyl]-1-piperazinyl]-3-pyridazinecarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	347.42

View Full Technical Details for PZ 3022

Technical Data
Citations

Biological Activity for PZ 3022

PZ 3022 is a potent allosteric pantothenate kinase (PanK) activator (EC₅₀=5.3 nM for PanK3). In a mouse model of propionic acidemia, treatment with PZ 3022 increases hepatic CoASH and C2-CoA, and decreases C3-CoA, improving intracellular C3:C2-CoA ratio and plasma C3:C2-carnitine ratios. PZ 3022 is orally bioavailable.

Licensing Information

Sold under license from St. Jude Children's Research Hospital

Technical Data for PZ 3022

M. Wt	347.42
Formula	C₂₀H₂₁N₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2170608-85-0
PubChem ID	132261124
InChi Key	CXSADKGUEBUMLH-UHFFFAOYSA-N
Smiles	N#CC1=NN=C(N2CCN(CC2)C(CC3=CC=C(C4CC4)C=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PZ 3022

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.74	100

Preparing Stock Solutions for PZ 3022

The following data is based on the product molecular weight 347.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.88 mL	14.39 mL	28.78 mL
5 mM	0.58 mL	2.88 mL	5.76 mL
10 mM	0.29 mL	1.44 mL	2.88 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for PZ 3022

References are publications that support the biological activity of the product.

Subramanian Pantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia. Sci.Transl.Med. 2021 PMID: 34524863